Structure of PDB 6nyy Chain B Binding Site BS02

Receptor Information
>6nyy Chain B (length=487) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VGETTAKVLKDEIDVKFKDVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKI
PKGAILTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPARVR
DLFALARKNAPCILFIDQIDAVGRKRGNFGGQSEQENTLNQLLVEMDGFN
TTTNVVILAGTNRPDILDPALLRPGRFDRQIFIGPPDIKGRASIFKVHLR
PLKLDSTLEKDKLARKLASLTPGFSGADVANVCNEAALIAARHLSDSINQ
KHFEQAIERVIGGLEKKTQVLQPEEKKTVAYHQAGHAVAGWYLEHADPLL
KVSIIPRGKGLGYAQYLPKEQYLYTKEQLLDRMCMTLGGRVSEEIFFGRI
TTGAQDDLRKVTQSAYAQIVQFGMNEKVGQISFDLPRQGDMVLEKPYSEA
TARLIDDEVRILINDAYKRTVALLTEKKADVEKVALLLLEKEVLDKNDMV
ELLGPRPFAEKSTYEEFVEGTGSLDEDTSLPEGLKDW
Ligand information
Receptor-Ligand Complex Structure
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PDB6nyy Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		F516 I553 Q575 G602 L603 G604 A606
Binding residue
(residue number reindexed from 1)		F224 I261 Q283 G310 L311 G312 A314
Enzymatic activity
Enzyme Commision number 3.4.24.-
3.6.-.-
Gene Ontology
Molecular Function
GO:0004176 ATP-dependent peptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6nyy, PDBe:6nyy, PDBj:6nyy
PDBsum6nyy
PubMed31327635
UniProtQ9Y4W6|AFG32_HUMAN Mitochondrial inner membrane m-AAA protease component AFG3L2 (Gene Name=AFG3L2)

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