Structure of PDB 6nk2 Chain B Binding Site BS02
Receptor Information
>6nk2 Chain B (length=179) Species:
9606
(Homo sapiens) [
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SQGPGEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNV
MSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLY
YAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGP
LTRKGFYLAFQDIGACVALLSVRVYYKKA
Ligand information
>6nk2 Chain D (length=13) Species:
32630
(synthetic construct) [
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WLAYPDSVPYRPK
Receptor-Ligand Complex Structure
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PDB
6nk2
Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling.
Resolution
2.2 Å
Binding residue
(original residue number in PDB)
G39 L54 M55 Q56 N57 M59 Y65 M66 C70 R103 F108 F156 R159 V161 C188 V189
Binding residue
(residue number reindexed from 1)
G17 L32 M33 Q34 N35 M37 Y43 M44 C48 R81 F86 F134 R137 V139 C166 V167
Enzymatic activity
Enzyme Commision number
2.7.10.1
: receptor protein-tyrosine kinase.
External links
PDB
RCSB:6nk2
,
PDBe:6nk2
,
PDBj:6nk2
PDBsum
6nk2
PubMed
31015204
UniProt
P29317
|EPHA2_HUMAN Ephrin type-A receptor 2 (Gene Name=EPHA2)
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