Structure of PDB 6j4x Chain B Binding Site BS02

Receptor Information
>6j4x Chain B (length=1157) Species: 644223 (Komagataella phaffii GS115) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DDTITTEDCWTVISAFFEEKGLVSQQLDSFDEFMETSIQDLVWEEPRLIL
DQPAQHDNINKRYEIRFGKIYLSRPTMTEADGTTHAMFPQEARLRNLTYS
SPVYLDMEKSMFTSIDGNKVHIGKVPIMLRSKFCSLRTLDEVDLYKMKEC
PYDMGGYFVINGSEKVLIAQERSAANIVQVFKKAAPSPISHVAEIRSALE
KGSRLISTMQIKLYGREDKGTGRTIKATLPYVKQDIPIVIVFRALGVVPD
GEILQHICYDENDWQMLEMLKPCIEEGFVIQDKEVALDFIGRRGSAALGI
RREKRIQYAKDILQKELLPHITQEEGFETRKTFFLGYMVNRLLLCALERK
DQDDRDHFGKKRLDLAGPLLANLFRILFRKLTREIYRYMQRCIETDRDFN
LNLAVKSTTITSGLKYSLATGNWGEQKKAMSSRAGVSQVLNRYTYSSTLS
HLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLLS
GISIGSPSEPIINFLEEWGMEPLEDYDPAQHTKSTRIFVNGVWTGIHRDP
SMLVSTMRDLRRSGAISPEVSIIRDIREREFKIFTDVGRVYRPLFIVEDD
ESKDNKGELRITKEHIRKIQQGYDDDVYGWSSLVTSGVIEYVDGEEEETI
MIAMTPEDLQTRSLNDTAKRIKPEMSTSSHHTFTHCEIHPSMILGVAASI
IPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQKPLAK
TQAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLF
FRSYMDQEKRFGISIVEEFEKPTRATTLRLKHGTYEKLDEDGLIAPGVRV
SGDDIIIGKTTPIPPYHTKRDASTPLRSTENGIVDQVLLTTNQEGLKFVK
VRMRTTKVPQIGDKFASRHGQKGTIGVTYRHEDMPFSAEGIVPDLIINPH
AIPSRMTVAHLIECLLSKVGSIRGYEGDATPFTDLTVDAVSNLLRDNGYQ
SRGFEVMYNGHTGKKLMAQVFFGPTYYQRLRHMVDDKIHARARGPVQVLT
RQPVEGRSRDGGLRFGEMERDCMIAHGAAGFLKERLMEASDAFRVHVCGI
CGLMSVIANLKKNQFECRSCKNKTNIYQLHIPYAAKLLFQELMAMNIAPR
LYTERSG
Ligand information
>6j4x Chain T (length=127) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
atcagaatcccggtgccgaggccgctcaattggtcgtagacagctctagc
accgcttaaacgcacgtacgcgctgtcccccgcgttttaaccgccaaggg
gattacacccaagacaccaggcacgag
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6j4x Structural insight into nucleosome transcription by RNA polymerase II with elongation factors.
Resolution4.3 Å
Binding residue
(original residue number in PDB)		T791 R942 G1121 R1122 R1129
Binding residue
(residue number reindexed from 1)		T736 R877 G1056 R1057 R1064
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0140727 siRNA-mediated pericentric heterochromatin formation
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex
GO:0005721 pericentric heterochromatin

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6j4x, PDBe:6j4x, PDBj:6j4x
PDBsum6j4x
PubMed30733384
UniProtC4QZQ7

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