Structure of PDB 6if3 Chain B Binding Site BS02

Receptor Information
>6if3 Chain B (length=177) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ARDYDHLFKLLIIGDSGVGKSSLLLRFADNTFSGSYITTIGVDFKIRTVE
INGEKVKLQIWDTAGLERFRTITSTYYRGTHGVIVVYDVTSAESFVNVKR
WLHEINQNCDDVCRILVGNKNDDPERKVVETEDAYKFAGQMGIQLFETSA
KENVNVEEMFNCITELVLRAKKDNLAK
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6if3 Chain B Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6if3 Rab35/ACAP2 and Rab35/RUSC2 Complex Structures Reveal Molecular Basis for Effector Recognition by Rab35 GTPase.
Resolution1.5 Å
Binding residue
(original residue number in PDB)		S22 T40
Binding residue
(residue number reindexed from 1)		S21 T39
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0019003 GDP binding
Biological Process
GO:0000281 mitotic cytokinesis
GO:0008104 protein localization
GO:0015031 protein transport
GO:0016197 endosomal transport
GO:0019882 antigen processing and presentation
GO:0031175 neuron projection development
GO:0032456 endocytic recycling
GO:0036010 protein localization to endosome
GO:0048227 plasma membrane to endosome transport
GO:1990090 cellular response to nerve growth factor stimulus
Cellular Component
GO:0005768 endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0010008 endosome membrane
GO:0030136 clathrin-coated vesicle
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031253 cell projection membrane
GO:0042470 melanosome
GO:0045171 intercellular bridge
GO:0045334 clathrin-coated endocytic vesicle
GO:0055038 recycling endosome membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6if3, PDBe:6if3, PDBj:6if3
PDBsum6if3
PubMed30905672
UniProtQ15286|RAB35_HUMAN Ras-related protein Rab-35 (Gene Name=RAB35)

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