Structure of PDB 6i8a Chain B Binding Site BS02

Receptor Information
>6i8a Chain B (length=1094) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NYALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVGW
LTNMHATLVSQQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDESRVN
DVEELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLSFVNSNQLF
EARKLLRPILQDNANNNVQRNIYNVDAKHLIEDIREYDVPYHVRVSIDKD
IRVGKWYKVTQQGFIEDTRKIAFADPVVMAFDIETTKPPLKFRDSAVDQI
MMISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNENDEVAL
LQRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGFAPDA
EGEYKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIELDPEL
MTPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDETL
RKGTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYVGGHV
ESLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDKVT
NFEEIKNQITQKLLELKENNIRNELPLIYHVDVASMYPNIMTTNRLQPDS
IKTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETFPNKTFDELSYADQV
IHIKKRLTEYVSEIVEREAIVCQRENPFYVDTVKSFRDRRYEFKGLAKTW
KGNLSKIDPSDKHARDEAKKMIVLYDSLQLAHKVILNSFYGYVMRKGSRW
YSMEMAGITCLTGATIIQMARALVERVGRPLELDTDGIWCILPKSFPETY
FFTLENGKKLYLSYPCSMLNYRVHQKFTNHQYQELKDPLNYIYETHSENT
IFFEVDGPYKAMILPSSKEEGKGIKKRYAVFNEDGSLAELKGFELKRRGE
LQLIKNFQSDIFKVFLEGDTLEGCYSAVASVCNRWLDVLDSHGLMLEDED
LVSLICENRSMSKTLKEYEGQKSTSITTARRLGDFLGEDMVKDKGLQCKY
IISSKPFNAPVTERAIPVAIFSADIPIKRSFLRRWTLDPSLEDLDIRTII
DWGYYRERLGSAIQKIITIPAALQGVSNPVPRVEHPDWLKRKIA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6i8a Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon.
Resolution2.652 Å
Binding residue
(original residue number in PDB)		D1028 D1031 S1032 R1173
Binding residue
(residue number reindexed from 1)		D937 D940 S941 R1082
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
Cellular Component
GO:0008622 epsilon DNA polymerase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6i8a, PDBe:6i8a, PDBj:6i8a
PDBsum6i8a
PubMed30670696
UniProtP21951|DPOE_YEAST DNA polymerase epsilon catalytic subunit A (Gene Name=POL2)

[Back to BioLiP]