Structure of PDB 6hzz Chain B Binding Site BS02

Receptor Information

>6hzz Chain B (length=516) Species: 9606 (Homo sapiens)

LKYEEIDCLINDEHTIKGRREGNEVFLPFTWVEKYFDVYGKVVQYDGYDR
FEFSHSYSKVYAQRAPYHPDGVFMSFEGYNVEVRDRVKCISGVEGVPLST
QWGPQGYFYPIQIAQYGLSHYSKNLTEKPPHIEVYETAEDRDKNKPNDWT
VPKGCFMANVADKSRFTNVKQFIAPETSEGVSLQLGNTKDFIISFDLKFL
TNGSVSVVLETTEKNQLFTIHYVSNAQLIAFKERDIYYGIGPRTSWSTVT
RDLVTDLRKGVGLSNTKAVKPTKIMPKKVVRLIAKGKGFLDNITISTTAH
MAAFFAASDWLVRNQDEKGGWPIMVTRKLGEGFKSLEPGWYSAMAQGQAI
STLVRAYLLTKDHIFLNSALRATAPYKFLSEQHGVKAVFMNKHDWYEEYP
TTPSSFVLNGFMYSLIGLYDLKETAGEKLGKEARSLYERGMESLKAMLPL
YDTGSGTIYDLRHFMLGIAPNLARWDYHTTHINQLQLLSTIDESPVFKEF
VKRWKSYLKGSRAKHN

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 6hzz Chain B Residue 1012

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6hzz Substrate binding mode and catalytic mechanism of human heparan sulfate d-glucuronyl C5 epimerase.
• Resolution: 2.52 Å
• Binding residue (original residue number in PDB): T238 E240 T268 N269 D392
• Binding residue (residue number reindexed from 1): T137 E139 T167 N168 D291
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 5.1.3.17: heparosan-N-sulfate-glucuronate 5-epimerase.

Gene Ontology

Molecular Function

• GO:0047464 heparosan-N-sulfate-glucuronate 5-epimerase activity

Biological Process

• GO:0015012 heparan sulfate proteoglycan biosynthetic process

External links

• PDB: RCSB:6hzz, PDBe:6hzz, PDBj:6hzz
• PDBsum: 6hzz
• PubMed: 30872481
• UniProt: O94923|GLCE_HUMAN D-glucuronyl C5-epimerase (Gene Name=GLCE)