Structure of PDB 6hys Chain B Binding Site BS02

Receptor Information
>6hys Chain B (length=633) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAE
AGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSP
ETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKT
VQKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPET
DYLDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEILYERMKSLGPDV
PELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYV
VDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYRLYT
ERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETL
ITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEE
MLTIVSMLSVQNVFYRPKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKN
NKFSNPWCYENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCGKSTVRVQ
KAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSALFNRQPEWVVYHEL
VLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPT
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6hys Chain B Residue 1302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6hys Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		T595 E686
Binding residue
(residue number reindexed from 1)		T41 E132
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome

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Molecular Function
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Biological Process
External links
PDB RCSB:6hys, PDBe:6hys, PDBj:6hys
PDBsum6hys
PubMed31409651
UniProtQ14562|DHX8_HUMAN ATP-dependent RNA helicase DHX8 (Gene Name=DHX8)

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