Structure of PDB 6hvm Chain B Binding Site BS02

Receptor Information

>6hvm Chain B (length=155) Species: 169963 (Listeria monocytogenes EGD-e)

SRIEREQHHLIESIEKSTQYMAKRRIGALISVARDTGMDDYIETGIPLNA
KISSQLLINIFIPNTPLHDGAVIIKGNEIASAASYLPLSDSPFLSKELGT
RHRAALGISEVTDSITIVVSEETGGISLTKGGELFRDVSEEELHKILLKE
LVTVT

Ligand information

• Ligand ID: FRU
• InChI: InChI=1S/C6H12O6/c7-1-3-4(9)5(10)6(11,2-8)12-3/h3-5,7-11H,1-2H2/t3-,4-,5+,6-/m1/s1
• InChIKey: RFSUNEUAIZKAJO-ARQDHWQXSA-N
• SMILES:
  ACDLabs 10.04: OC1C(O)C(OC1(O)CO)CO
  OpenEye OEToolkits 1.5.0: C([C@@H]1[C@H]([C@@H]([C@](O1)(CO)O)O)O)O
  CACTVS 3.341: OC[CH]1O[C](O)(CO)[CH](O)[CH]1O
  OpenEye OEToolkits 1.5.0: C(C1C(C(C(O1)(CO)O)O)O)O
  CACTVS 3.341: OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O
• Formula: C6 H12 O6
• Name: beta-D-fructofuranose;
  beta-D-fructose;
  D-fructose;
  fructose
• ChEMBL: CHEMBL604608
• ZINC: ZINC000001529270
• PDB chain: 6hvm Chain C Residue 2

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6hvm Crystal structures of the c-di-AMP-synthesizing enzyme CdaA.
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): Q9 A35 G78 L153
• Binding residue (residue number reindexed from 1): Q7 A33 G76 L151
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.7.85: diadenylate cyclase.

Gene Ontology

Molecular Function

• GO:0004016 adenylate cyclase activity

Biological Process

• GO:0006171 cAMP biosynthetic process

External links

• PDB: RCSB:6hvm, PDBe:6hvm, PDBj:6hvm
• PDBsum: 6hvm
• PubMed: 31118276
• UniProt: Q8Y5E4|DACA_LISMO Diadenylate cyclase (Gene Name=dacA)