Structure of PDB 6hdu Chain B Binding Site BS02

Receptor Information
>6hdu Chain B (length=170) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMQAPHKEHLYKLLVIGDLGVGKTSIIKRYVHQNFSSHYRATIGVDFALK
VLHWDPETVVRLQLWDIAGLERFGNMTRVYYREAMGAFIVFDVTRPATFE
AVAKWKNDLDSKLSLPNGKPVSVVLLANKCDQMDQFCKEHGFVGWFETSA
KENINIDEASRCLVKHILAN
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6hdu Chain B Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6hdu LRRK2 binds to the Rab32 subfamily in a GTP-dependent mannerviaits armadillo domain.
Resolution1.793 Å
Binding residue
(original residue number in PDB)		T23 T41
Binding residue
(residue number reindexed from 1)		T24 T42
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0031982 vesicle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6hdu, PDBe:6hdu, PDBj:6hdu
PDBsum6hdu
PubMed31552791
UniProtP57729|RAB38_HUMAN Ras-related protein Rab-38 (Gene Name=RAB38)

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