Structure of PDB 6h68 Chain B Binding Site BS02

Receptor Information
>6h68 Chain B (length=1175) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ARTADFRTLERESRFINPPKDKSAFPLLQEAVQPHIGSFNALTEGPDGGL
LNLGVKDIGEKVIFDGKPLNSNSGYLGNKLSVSVEQVSIAKPMSNDGVSS
AVERKVYPSESRQRLTSYRGKLLLKLKWSVNNGEENLFEVRDCGGLPVML
QSNRCHLNKMSPYELVQHKEESDEIGGYFIVNGIEKLIRMLIVQRRNHPM
AIIRPSFANRGASYSHYGIQIRSVRPDQTSQTNVLHYLNDGQVTFRFSWR
KNEYLVPVVMILKALCHTSDREIFDGIIGNDVKDSFLTDRLELLLRGFKK
RYPHLQNRTQVLQYLGDKFRVVFQASPDQSDLEVGQEVLDRIVLVHLGKD
GSQDKFRMLLFMIRKLYSLVAGECSPDNPDATQHQEVLLGGFLYGMILKE
KIDEYLQNIIAQVRMDINRGMAINFKDKRYMSRVLMRVNENIGSKMQYFL
STGNLVSQSGLDLQQVSGYTVVAEKINFYRFISHFRMVHRGSFFAQLKTT
TVRKLLPESWGFLCPVHTPDGSPCGLLNHFAHKCRISTQQSDVSRIPSIL
YSLGVAPASHTFAAGPSLCCVQIDGKIIGWVSHEQGKIIADTLRYWKVEG
KTPGLPIDLEIGYVPPSTRGQYPGLYLFGGHSRMLRPVRYLPLDKEDIVG
PFEQVYMNIAVTPQEIQNNVHTHVEFTPTNILSILANLTPFSDFNQSPRN
MYQCQMGKQTMGTPGVALCHRSDNKLYRLQTGQTPIVKANLYDDYGMDNF
PNGFNAVVAVISYTGYDMDDAMIINKSADERGFGYGTMYKTEKVDLALNG
DPITQHFGFGNDEWPKEWLEKLDEDGLPYIGTYVEEGDPICAYFDDTLNK
TKIKTYHSSEPAYIEEVNLIGDESNKFQELQTVSIKYRIRRTPQIGDKFS
SRHGQKGVCSRKWPTIDMPFSETGIQPDIIINPHAFPSRMTIGMFVESLA
GKAGALHGIAQDSTPWIFNEDDTPADYFGEQLAKAGYNYHGNEPMYSGAT
GEELRADIYVGVVYYQRLRHMVNDKFQVRSTGPVNSLTMQPVKGRKRHGG
IRVGEMERDALIGHGTSFLLQDRLLNSSDYTQASVCRECGSILTTQQSVP
RIGSISTVCCRRCSMRFEDAKKLFIDDSQIWEDGQGNKFVGGNETTTVAI
PFVLKYLDSELSAMGIRLRYNVEPK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6h68 Structural basis of RNA polymerase I stalling at UV light-induced DNA damage.
Resolution4.6 Å
Binding residue
(original residue number in PDB)		I199 M430 S466 K513 N739 K740 Q1045 R1063 K1064 R1070
Binding residue
(residue number reindexed from 1)		I184 M415 S451 K498 N724 K725 Q1027 R1045 K1046 R1052
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001054 RNA polymerase I activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006360 transcription by RNA polymerase I
GO:0006361 transcription initiation at RNA polymerase I promoter
GO:0006362 transcription elongation by RNA polymerase I
GO:0006363 termination of RNA polymerase I transcription
GO:0042254 ribosome biogenesis
GO:0042790 nucleolar large rRNA transcription by RNA polymerase I
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005736 RNA polymerase I complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6h68, PDBe:6h68, PDBj:6h68
PDBsum6h68
PubMed30127008
UniProtP22138|RPA2_YEAST DNA-directed RNA polymerase I subunit RPA135 (Gene Name=RPA135)

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