Structure of PDB 6fws Chain B Binding Site BS02

Receptor Information
>6fws Chain B (length=683) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALTAALKAQIAAWYKALQEQIPDFIPRAPQRQMIADVAKTLAGEEGRHLA
IEAPTGVGKTLSYLIPGIAIAREEQKTLVVSTANVALQDQIYSKDLPLLK
KIIPDLKFTAAFGRGRYVCPRNLTALASTEPTQQDLLAFLDDELTPNNQE
EQKRCAKLKGDLDTYKWDGLRDHTDIAIDDDLWRRLSTCPFFVARREIQE
AEVVVANHALVMAAMESEAVLPDPKNLLLVLDEGHHLPDVARDALEMSAE
ITAPWYRLQLDLFTKLVATCMEQFRPKTIPPLAIPERLNAHCEELYELIA
SLNNILNLYMPAGQEAEHRFAMGELPDEVLEICQRLAKLTEMLRGLAELF
LNDLSEKDIVRLHRLILQMNRALGMFEAQSKLWRLASLAQSSGAPVTKWA
TREEREGQLHLWFHCVGIRVSDQLERLLWRSIPHIIVTSATLRSLNSFSR
LQEMSGLKEKAGDRFVALDSPFNHCEQGKIVIPRMRVEPSIDNEEQHIAE
MAAFFREQVESKKHLGMLVLFASGRAMQRFLDYVTDLRLMLLVQGDQPRY
RLVELHRKRVANGERSVLVGLQSFAEGLDLKGDLLSQVHIHKIAFPPIDS
PVVITEGEWLKSLNRYPFEVQSLPSASFNLIQQVGRLIRSHGCWGEVVIY
DKRLLTKNYGKRLLDALPVFPIEQPEVPEGIVK
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain6fws Chain B Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6fws DNA translocation mechanism of an XPD family helicase.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		R115 C120 P121 C205 F208
Binding residue
(residue number reindexed from 1)		R114 C119 P120 C189 F192
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0016853 isomerase activity
GO:0016887 ATP hydrolysis activity
GO:0033677 DNA/RNA helicase activity
GO:0043139 5'-3' DNA helicase activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006281 DNA repair
GO:0009432 SOS response
GO:0032508 DNA duplex unwinding
GO:0044806 G-quadruplex DNA unwinding

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6fws, PDBe:6fws, PDBj:6fws
PDBsum6fws
PubMed30520735
UniProtP27296|DING_ECOLI ATP-dependent DNA helicase DinG (Gene Name=dinG)

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