Structure of PDB 6fwk Chain B Binding Site BS02

Receptor Information
>6fwk Chain B (length=1099) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVGWL
TNMHATLVSQENQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDESRV
NDVEELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLSFVNSNQL
FEARKLLRPILQDNANNNVQRNIYNVVDAKHLIEDIREYDVPYHVRVSID
KDIRVGKWYKVTQQGFIEDTRKIAFADPVVMAFDIETTKPPLKFPDSAVD
QIMMISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNENDEV
ALLQRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGFAP
DAEGEYKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIELDP
ELMTPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDE
TLRKGTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYVGG
HVESLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDK
VTNFEEIKNQITQKLLELKENNIRNELPLIYHVDVASGYPNIMTTNRLQP
DSIKTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETFPNLTFDELSYAD
QVIHIKKRLTEYSRKVSEIVEREAIVCQRENPFYVDTVKSFRDRRYEFKG
LAKTWKGNLSKIDPSDKHARDEAKKMIVLYDSLQLAHKVILNSFYGYVMR
KGSRWYSMEMAGITCLTGATIIQMARALVERVGRPLELDTDGIWCILPKS
FPETYFFTLENGKKLYLSYPCSMLNYRVHQKFTNHQYQELKDPLNYIYET
HSENTIFFEVDGPYKAMILPSSKEEGKGIKKRYAVFNEDGSLAELKGFEL
KRRGELQLIKNFQSDIFKVFLEGDTLEGCYSAVASVCNRWLDVLDSHGLM
LEDEDLVSLICENRSMSKTLKEYEGQKSTSITTARRLGDFLGEDMVKDKG
LQCKYIISSKPFNAPVTERAIPVAIFSADIPIKRSFLRRWTLDPSLEDLD
IRTIIDWGYYRERLGSAIQKIITIPAALQGVSNPVPRVEHPDWLKRKIA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6fwk Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon.
Resolution2.503 Å
Binding residue
(original residue number in PDB)		D1028 D1031 R1173
Binding residue
(residue number reindexed from 1)		D942 D945 R1087
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
Cellular Component
GO:0008622 epsilon DNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6fwk, PDBe:6fwk, PDBj:6fwk
PDBsum6fwk
PubMed30670696
UniProtP21951|DPOE_YEAST DNA polymerase epsilon catalytic subunit A (Gene Name=POL2)

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