Structure of PDB 6fqm Chain B Binding Site BS02

Receptor Information

>6fqm Chain B (length=156) Species: 158879 (Staphylococcus aureus subsp. aureus N315) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DCSKSPEECEIFLVEGDSGRRTQAILPLRGKILNVEKARLDRILNNNEIR
QMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMR
PLIEAGYVYIAQPTTMNPEALLQVKLEDAIEADQTFEMLMGDVVENRRQF
IEDNAV

Ligand information

>6fqm Chain F (length=20) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gagagtatggccatactctt

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6fqm A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance.
Resolution	3.06 Å
Binding residue (original residue number in PDB)	E435 G459 D512
Binding residue (residue number reindexed from 1)	E15 G30 D83

Enzymatic activity

Enzyme Commision number

5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524	ATP binding

	Biological Process
GO:0006265	DNA topological change

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Molecular Function

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Biological Process

External links

PDB	RCSB:6fqm, PDBe:6fqm, PDBj:6fqm
PDBsum	6fqm
PubMed	29538767
UniProt	P66937\|GYRB_STAAN DNA gyrase subunit B (Gene Name=gyrB)

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