Structure of PDB 6fie Chain B Binding Site BS02

Receptor Information
>6fie Chain B (length=255) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPHMAESHLQSSLITASQFFEIWLHFDADGSGYLEGKELQNLIQELQQAR
KKAGLELSPEMKTFVDQYKIGIVELAHVLPTEENFLLLFRCQQLKSCEEF
MKTWRKYDTDHSGFIETEELKNFLKDLLEKANKTVDDTKLAEYTDLMLKL
FDSNNDGKLELTEMARLLPVQENFLLKFQGIKMCGKEFNKAFELYDQDGN
GYIDENELDALLKDLCEKNKQDLDINNITTYKKNIMALSDGGKLYRTDLA
LILCA
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6fie Chain B Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6fie The X-ray structure of human calbindin-D28K: an improved model.
Resolution1.51 Å
Binding residue
(original residue number in PDB)		D111 D113 S115 F117 E119 E122
Binding residue
(residue number reindexed from 1)		D108 D110 S112 F114 E116 E119
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005499 vitamin D binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
GO:0099534 calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration
GO:0099567 calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration
Biological Process
GO:0007611 learning or memory
GO:0007614 short-term memory
GO:0007616 long-term memory
GO:0007626 locomotory behavior
GO:0010842 retina layer formation
GO:0010996 response to auditory stimulus
GO:0035502 metanephric part of ureteric bud development
GO:0048167 regulation of synaptic plasticity
GO:0055074 calcium ion homeostasis
GO:0060041 retina development in camera-type eye
GO:0072205 metanephric collecting duct development
GO:0072221 metanephric distal convoluted tubule development
GO:0072286 metanephric connecting tubule development
GO:0090102 cochlea development
GO:0099509 regulation of presynaptic cytosolic calcium ion concentration
GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration
GO:1900271 regulation of long-term synaptic potentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030424 axon
GO:0030425 dendrite
GO:0032420 stereocilium
GO:0032437 cuticular plate
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043195 terminal bouton
GO:0043197 dendritic spine
GO:0044305 calyx of Held
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:0098686 hippocampal mossy fiber to CA3 synapse
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse
GO:0098982 GABA-ergic synapse
GO:0099523 presynaptic cytosol
GO:0099524 postsynaptic cytosol

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6fie, PDBe:6fie, PDBj:6fie
PDBsum6fie
PubMed30289411
UniProtP05937|CALB1_HUMAN Calbindin (Gene Name=CALB1)

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