Structure of PDB 6fhi Chain B Binding Site BS02

Receptor Information
>6fhi Chain B (length=750) Species: 1129347 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDVNPMLIFLKVPVQNAISTTFPYTGDPPYSHGTGTGYTMDTVIRTHDYS
SRGIWKTNSETGAQQLNPIDGPLPEDNEPSGYAQTDCVLELIEGLDRSHP
GLFETACQETIDAIQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF
RKNGYKLNESGRLIDFLKDVLLSFENDSMEVTTHFQKKKRIRDNKKMITQ
RTIGKKRVKLTKKNYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFV
YFVELLARNICERLEQSGLPVGGNEKKAKLANVIKKMMAKSTDEELSYTI
TGDNTKWNENQNPRIFLAMVLRITAGQPEWFRDLLAVAPIMFSNKVARLG
RGYMFESKSMHLRTQISAENLSDINLRYFNEDTKKKIEKIRHLMVEGTAS
LSPGMMMGMFNMLSTVLGVSVLNLGQREILKRTYWWDGLQSSDDFALIIN
GHFKEDIQQGVNHFYRTCKLVGINMSQKKSYINKTGTFEFTSFFYRYGFV
ANFSMELPSFGVAGNNESADMSIGTTVIKTNMINNDLGPATAQMAIQLFI
KDYRYTYRCHRGDTNLETRRTKSIKRLWTETISKAGLLVADGGPNPYNLR
NLHIPEVCLKWSLMDPDYRGRLCNPNNPFVHHMEVESTNLAVVMPGPAKS
LEYDAVATTHSWTPKRNRSILNTNQRGILEDERIYQKCCQVFEKFFPSST
YRRPIGMASMLDAMLSRARIDARIDLESGRISSQDFSEITNTCKAIEALK
Ligand information
Receptor-Ligand Complex Structure
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PDB6fhi Towards New Anti-Influenza Therapeutics: Structure-Activity Relationships in the Interaction between Heterotrimeric Influenza Polymerase and Pol II C-terminal domain
Resolution2.8 Å
Binding residue
(original residue number in PDB)		H32 T34 Y38 K188 R190 T201 R203 M356 R365
Binding residue
(residue number reindexed from 1)		H32 T34 Y38 K188 R190 T199 R201 M354 R363
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0005737 cytoplasm
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6fhi, PDBe:6fhi, PDBj:6fhi
PDBsum6fhi
PubMed
UniProtH6QM91

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