Structure of PDB 6evk Chain B Binding Site BS02

Receptor Information
>6evk Chain B (length=748) Species: 1129347 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDVNPMLIFLKVPVQNAISTTFPYTGDPPYSHGTGTGYTMDTVIRTHDYS
SRGIWKTNSETGAQQLNPIDGPLPEDNEPSGYAQTDCVLELIEGLDRSHP
GLFETACQETIDAIQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF
RKNGYKLNESGRLIDFLKDVLLSFENDSMEVTTHFQKKKRIRDNMITQRT
IGKKRVKLTKKNYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYF
VELLARNICERLEQSGLPVGGNEKKAKLANVIKKMMAKSTDEELSYTITG
DNTKWNENQNPRIFLAMVLRITAGQPEWFRDLLAVAPIMFSNKVARLGRG
YMFESKSMHLRTQISAENLSDINLRYFNEDTKKKIEKIRHLMVEGTASLS
PGMMMGMFNMLSTVLGVSVLNLGQREILKRTYWWDGLQSSDDFALIINGH
FKEDIQQGVNHFYRTCKLVGINMSQKKSYINKTGTFEFTSFFYRYGFVAN
FSMELPSFGVAGNNESADMSIGTTVIKTNMINNDLGPATAQMAIQLFIKD
YRYTYRCHRGDTNLETRRTKSIKRLWTETISKAGLLVADGGPNPYNLRNL
HIPEVCLKWSLMDPDYRGRLCNPNNPFVHHMEVESTNLAVVMPGPAKSLE
YDAVATTHSWTPKRNRSILNTNQRGILEDERIYQKCCQVFEKFFPSSTYR
RPIGMASMLDAMLSRARIDARIDLESGRISSQDFSEITNTCKAIEALK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6evk Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		H32 T34 Y38 K188 T201 R203 M356 R365
Binding residue
(residue number reindexed from 1)		H32 T34 Y38 K188 T197 R199 M352 R361
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0005737 cytoplasm
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6evk, PDBe:6evk, PDBj:6evk
PDBsum6evk
PubMed29202182
UniProtH6QM91

[Back to BioLiP]