Structure of PDB 6eu0 Chain B Binding Site BS02

Receptor Information
>6eu0 Chain B (length=1112) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
INTAQDKWHLLPAFLKVKGLVKQHLDSFNYFVDTDLKKIIKANQLILSDV
DPEFYLKYVDIRVGKKSSSSTKDYLTPPHECRLRDMTYSAPIYVDIEYTR
GRNIIMHKDVEIGRMPIMLRSNKCILYDADESKMAKLNECPLDPGGYFIV
NGTEKVILVQEQLSKNRIIVEADEKKGIVQASVTSSTHERKSKTYVITKN
GKIYLKHNSIAEEIPIAIVLKACGILSDLEIMQLVCGNDSSYQDIFAVNL
EESSKLDIYTQQQALEYIGAKVKTMRRQKLTILQEGIEAIATTVIAHLTV
EALDFREKALYIAMMTRRVVMAMYNPKMIDDRDYVGNKRLELAGQLISLL
FEDLFKKFNNDFKLSIDKVLKKPNRAMEYDALLSINVHSNNITSGLNRAI
STGNWSLKRFKMERAGVTHVLSRLSYISALGMMTRISSQFEKSRKVSGPR
ALQPSQFGMLCTADTPEGEACGLVKNLALMTHITTDDEEEPIKKLCYVLG
VEDITLIDSASLHLNYGVYLNGTLIGSIRFPTKFVTQFRHLRRTGKVSEF
ISIYSNSHQMAVHIATDGGRICRPLIIVSDGQSRVKDIHLRKLLDGELDF
DDFLKLGLVEYLDVNEENDSYIALYEKDIVPSMTHLEIEPFTILGAVAGL
IPYPHHNQSPRNTYQCAMGKQAIGAIAYNQFKRIDTLLYLMTYPQQPMVK
TKTIELIDYDKLPAGQNATVAVMSYSGYDIEDALVLNKSSIDRGFGRCET
RRKTTTVLKRYANHTQDIIGGMRVDENGDPIWQHQSLGPDGLGEVGMKVQ
SGQIYINKSVPTNSADAPNPNNVNVQTQYREAPVIYRGPEPSHIDQVMMS
VSDNDQALIKVLLRQNRRPELGDKFSSRHGQKGVCGIIVKQEDMPFNDQG
IVPDIIMNPHGFPSRMTVGKMIELISGKAGVLNGTLEYGTCFGGSKLEDM
SKILVDQGFNYSGKDMLYSGITGECLQAYIFFGPIYYQKLKHMVLDKMHA
RARGPRAVLTRQPTEGRSRDGGLRLGEMERDCVIAYGASQLLLERLMISS
DAFEVDVCDKCGLMGYSGWCTTCKSAENIIKMTIPYAAKLLFQELLSMNI
APRLRLEDIFQQ
Ligand information
>6eu0 Chain S (length=57) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgaagggttacttcgcgaacacatgcgaaaaaaacatttttttatagtag
ccgaaaa
Receptor-Ligand Complex Structure
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PDB6eu0 Structural basis of RNA polymerase III transcription initiation.
Resolution4.0 Å
Binding residue
(original residue number in PDB)		R1054 R1061 E1064
Binding residue
(residue number reindexed from 1)		R1017 R1024 E1027
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006383 transcription by RNA polymerase III
GO:0006384 transcription initiation at RNA polymerase III promoter
GO:0006386 termination of RNA polymerase III transcription
GO:0042797 tRNA transcription by RNA polymerase III
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 RNA polymerase III complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6eu0, PDBe:6eu0, PDBj:6eu0
PDBsum6eu0
PubMed29345637
UniProtP22276|RPC2_YEAST DNA-directed RNA polymerase III subunit RPC2 (Gene Name=RET1)

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