Structure of PDB 6eem Chain B Binding Site BS02

Receptor Information
>6eem Chain B (length=488) Species: 3469 (Papaver somniferum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QNPLDPDEFRRQGHMIIDFLADYYKNVEKYPVRSQVEPGYLKKRLPESAP
YNPESIETILEDVTNDIIPGLTHWQSPNYFAYFPSSGSIAGFLGEMLSTG
FNVVGFNWMSSPAATELESIVMNWLGQMLTLPKSFLFSSDGGGGGVLQGT
TCEAILCTLTAARDKMLNKIGRENINKLVVYASDQTHCALQKAAQIAGIN
PKNVRAIKTSKATNFGLSPNSLQSAILADIESGLVPLFLCATVGTTSSTA
VDPIGPLCAVAKLYGIWVHIDAAYAGSACICPEFRHFIDGVEDADSFSLN
AHKWFFTTLDCCCLWVKDSDSLVKALSTSPEYLKNKQVIDYKDWQIALSR
RFRSMKLWLVLRSYGVANLRTFLRSHVKMAKHFQGLIGMDNRFEIVVPRT
FAMVCFRLKPTAIFKQKIVDNDYIEDQTNEVNVKLLESVNASGKIYMTHA
VVGGVYMIRFAVGATLTEERHVTGAWKVVQEHTDAILG
Ligand information
Ligand IDTYR
InChIInChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1
InChIKeyOUYCCCASQSFEME-QMMMGPOBSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(N)Cc1ccc(O)cc1
OpenEye OEToolkits 1.5.0c1cc(ccc1C[C@@H](C(=O)O)N)O
OpenEye OEToolkits 1.5.0c1cc(ccc1CC(C(=O)O)N)O
CACTVS 3.341N[CH](Cc1ccc(O)cc1)C(O)=O
CACTVS 3.341N[C@@H](Cc1ccc(O)cc1)C(O)=O
FormulaC9 H11 N O3
NameTYROSINE
ChEMBLCHEMBL925
DrugBankDB00135
ZINCZINC000000266964
PDB chain6eem Chain B Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6eem Structural basis for divergent and convergent evolution of catalytic machineries in plant aromatic amino acid decarboxylase proteins.
Resolution2.61001 Å
Binding residue
(original residue number in PDB)		W90 Y98 F99 P100 H320 X321
Binding residue
(residue number reindexed from 1)		W74 Y82 F83 P84 H302 X303
Annotation score5
Enzymatic activity
Enzyme Commision number 4.1.1.25: tyrosine decarboxylase.
Gene Ontology
Molecular Function
GO:0004837 tyrosine decarboxylase activity
GO:0016830 carbon-carbon lyase activity
GO:0016831 carboxy-lyase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006520 amino acid metabolic process
GO:0019752 carboxylic acid metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6eem, PDBe:6eem, PDBj:6eem
PDBsum6eem
PubMed32371491
UniProtO82415|TYDC_PAPSO Tyrosine decarboxylase (Gene Name=TYDC)

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