Structure of PDB 6dcl Chain B Binding Site BS02

Receptor Information
>6dcl Chain B (length=171) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGF
GFVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKI
FVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDKRGFAFVTFDDHDSVDKI
VIQKYHTVNGHNCEVRKALSK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6dcl Structural basis for terminal loop recognition and stimulation of pri-miRNA-18a processing by hnRNP A1.
Resolution2.497 Å
Binding residue
(original residue number in PDB)		Q12 K15 F17 G20 M46 R55 G56 F57 F59 E85 K87 A89 V90 R92 S95 H101
Binding residue
(residue number reindexed from 1)		Q5 K8 F10 G13 M39 R48 G49 F50 F52 E78 K80 A82 V83 R85 S88 H94
Binding affinityPDBbind-CN: Kd=15.5nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding

View graph for
Molecular Function
External links
PDB RCSB:6dcl, PDBe:6dcl, PDBj:6dcl
PDBsum6dcl
PubMed29946118
UniProtP09651|ROA1_HUMAN Heterogeneous nuclear ribonucleoprotein A1 (Gene Name=HNRNPA1)

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