Structure of PDB 6d9s Chain B Binding Site BS02

Receptor Information

>6d9s Chain B (length=180) Species: 1392 (Bacillus anthracis)

AMMNQDIEKVLISEEQIQEKVLELGAIIAEDYKNTVPLAIGVLKGAMPFM
ADLLKRTDTYLEMDFMAVSSYGHSTVSTGEVKILKDLDTSVEGRDILIVE
DIIDSGLTLSYLVDLFKYRKAKSVKIVTLLDKPTGRKVDLKADYVGFTVP
HEFVVGYGLDYKEQYRNLPYVGVLKPSVYS

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 6d9s Chain B Residue 202

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6d9s Evolution of (p)ppGpp-HPRT regulation through diversification of an allosteric oligomeric interaction.
• Resolution: 2.105 Å
• Binding residue (original residue number in PDB): D159 R165
• Binding residue (residue number reindexed from 1): D160 R166
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): E99 D100 D103 F152 R165
• Catalytic site (residue number reindexed from 1): E100 D101 D104 F153 R166
• Enzyme Commision number: 2.4.2.8: hypoxanthine phosphoribosyltransferase.

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0000287 magnesium ion binding
• GO:0004422 hypoxanthine phosphoribosyltransferase activity
• GO:0016757 glycosyltransferase activity
• GO:0046872 metal ion binding
• GO:0052657 guanine phosphoribosyltransferase activity

Biological Process

• GO:0006166 purine ribonucleoside salvage
• GO:0006178 guanine salvage
• GO:0032263 GMP salvage
• GO:0032264 IMP salvage
• GO:0046100 hypoxanthine metabolic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:6d9s, PDBe:6d9s, PDBj:6d9s
• PDBsum: 6d9s
• PubMed: 31552824
• UniProt: B9ZW32