Structure of PDB 6cvo Chain B Binding Site BS02

Receptor Information
>6cvo Chain B (length=178) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMGHWSQGLKISMQDPKMQVYKDEQVVVIKDKYPKARYHWLVLPWTSISS
LKAVAREHLELLKHMHTVGEKVIVDFAGSSKLRFRLGYHAIPSMSHVHLH
VISQDFDSPCLKNKKHWNSFNTEYFLESQAVIEMVQEAGRVTVRDGMPEL
LKLPLRCHECQQLLPSIPQLKEHLRKHW
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6cvo Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		W167 Y195 K197 S255 K277 H278
Binding residue
(residue number reindexed from 1)		W5 Y33 K35 S93 K115 H116
Enzymatic activity
Enzyme Commision number 3.6.1.71: adenosine-5'-diphospho-5'-[DNA] diphosphatase.
3.6.1.72: DNA-3'-diphospho-5'-guanosine diphosphatase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:6cvo, PDBe:6cvo, PDBj:6cvo
PDBsum6cvo
PubMed29934293
UniProtQ7Z2E3|APTX_HUMAN Aprataxin (Gene Name=APTX)

[Back to BioLiP]