Structure of PDB 6cst Chain B Binding Site BS02

Receptor Information
>6cst Chain B (length=442) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQ
QKAQITSQQLRKAQLQVDRFAMELEQSRNLSNTIVHIDMDAFYAAVEMRD
NPELKDKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPP
NFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEERQNWPEDKR
RYFIKNSVVFGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDK
NKPNGQYQILPNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTEL
YQQRALLSLLFSETSWHYFLHISLGLGSTHLTRDGERKSMSVERTFSEIN
KAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSS
VVSTAEEIFAIAKELLKTEIDADFPHPLRLRLMGVRISSFPN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6cst 2.0 angstrom resolution crystal structure of human pol kappa reveals a new catalytic function of N-clasp in DNA replication.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		S196 K321 G356 G358 V360 T361 R454 T469 R470 A471 S472 T473
Binding residue
(residue number reindexed from 1)		S177 K245 G280 G282 V284 T285 R378 T393 R394 A395 S396 T397
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6cst, PDBe:6cst, PDBj:6cst
PDBsum6cst
PubMed30310122
UniProtQ9UBT6|POLK_HUMAN DNA polymerase kappa (Gene Name=POLK)

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