Structure of PDB 6brx Chain B Binding Site BS02

Receptor Information
>6brx Chain B (length=430) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRK
AQLQVDRFAMELEQSRNLSNTIVHIDMDAFYAAVEMRDNPELKDKPIAVG
SMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEV
KEILADYDPNFMAMSLDEAYLNITKHLEERQNWPEDKRRYFIKNSVVFGT
SAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPN
RQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQRALLSLLFS
ETSWHYFLHISLGLGSTHLTRDGERKSMSVERTFSEINKAEEQYSLCQEL
CSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVSTAEEIFAIA
KELLKTEIDADFPHPLRLRLMGVRISSFPN
Ligand information
Receptor-Ligand Complex Structure
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PDB6brx Structural Basis for Human DNA Polymerase Kappa to Bypass Cisplatin Intrastrand Cross-Link (Pt-GG) Lesion as an Efficient and Accurate Extender.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		R63 E199 K321 G356 I357 G358 V360 T361 R454 T469 R470 S472 T473
Binding residue
(residue number reindexed from 1)		R32 E168 K233 G268 I269 G270 V272 T273 R366 T381 R382 S384 T385
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6brx, PDBe:6brx, PDBj:6brx
PDBsum6brx
PubMed29715472
UniProtQ9UBT6|POLK_HUMAN DNA polymerase kappa (Gene Name=POLK)

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