Structure of PDB 6avi Chain B Binding Site BS02

Receptor Information
>6avi Chain B (length=259) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLM
MGEDKIKFKHIKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLND
QVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDF
MEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNL
LQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETHP
LLQEIYKDL
Ligand information
Ligand IDKNA
InChIInChI=1S/C9H18O2/c1-2-3-4-5-6-7-8-9(10)11/h2-8H2,1H3,(H,10,11)
InChIKeyFBUKVWPVBMHYJY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 12.01O=C(O)CCCCCCCC
OpenEye OEToolkits 1.7.2CCCCCCCCC(=O)O
CACTVS 3.370CCCCCCCCC(O)=O
FormulaC9 H18 O2
Namenonanoic acid
ChEMBLCHEMBL108436
DrugBank
ZINCZINC000001529234
PDB chain6avi Chain B Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6avi Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPAR gamma.
Resolution2.29 Å
Binding residue
(original residue number in PDB)		G284 C285 I341 S342 M364
Binding residue
(residue number reindexed from 1)		G71 C72 I128 S129 M151
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6avi, PDBe:6avi, PDBj:6avi
PDBsum6avi
PubMed30575522
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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