Structure of PDB 5zse Chain B Binding Site BS02

Receptor Information

>5zse Chain B (length=775) Species: 9544 (Macaca mulatta)

ARWFPKTLPCDVTLDVSKNHVIVDCTDKHLTEIPGGIPTNTTNLTLTINH
IPDISPASFHRLVHLVEIDFRCNCVPIRLGSKSNMCPRRLQIKPRSFSGL
TYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKEQLTELANIEI
LYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTTVPTVLPST
LTELYLYNNMIAEIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCTPCKNN
SPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINNLQELDLSQNFL
AKEIGDAKFLHFLPNLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILR
IRGYVFKELKSFQLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVI
DLSVNKISPVLEQLYYFRYDKYARSCRFKSCYKYGQTLDLSKNSIFFIKS
SDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHST
AFEELRKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISS
STSRTMESESLRTLEFRGNHLDVLWRDGDNRYLQLFKNLLKLEELDISKN
SLSFLPSGVFDGMPPNLKNLSLAKNGLKSFIWEKLRYLKNLETLDLSHNQ
LTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQ
MIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVQHTEVTIPYLAT
DVTCVGPGAHKGQSVISLDLYTCEL

Ligand information

>5zse Chain D (length=5)

guccc

.....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5zse To be published
• Resolution: 2.201 Å
• Binding residue (original residue number in PDB): I74 H76 L105 G106 S107 D135 E156 Q181 Y184 R186 R467 D469 A472 R473 S474 C475
• Binding residue (residue number reindexed from 1): I48 H50 L79 G80 S81 D109 E130 Q155 Y158 R160 R418 D420 A423 R424 S425 C426

Gene Ontology

Molecular Function

• GO:0004888 transmembrane signaling receptor activity

Biological Process

• GO:0002224 toll-like receptor signaling pathway
• GO:0006955 immune response

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:5zse, PDBe:5zse, PDBj:5zse
• PDBsum: 5zse
• PubMed: 30566863
• UniProt: B3Y653