Structure of PDB 5zob Chain B Binding Site BS02

Receptor Information

>5zob Chain B (length=156) Species: 64320 (Zika virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KGETTDGVYRVMTRRLLGSTQVGVGVMQEGVFHTMWHVTKGAALRSGEGR
LDPYWGDVKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERAKNIQTLPG
IFKTKDGDIGAVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSA
ITQGKR

Ligand information

>5zob Chain J (length=4) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gRRR

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5zob Structures of Zika virus NS2B-NS3 protease in complex with peptidomimetic inhibitors.
Resolution	2.0 Å
Binding residue (original residue number in PDB)	V36 H51 S135
Binding residue (residue number reindexed from 1)	V22 H37 S121

Enzymatic activity

Enzyme Commision number

2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003724	RNA helicase activity
GO:0005524	ATP binding

View graph for
Molecular Function

External links

PDB	RCSB:5zob, PDBe:5zob, PDBj:5zob
PDBsum	5zob
PubMed	30315877
UniProt	Q32ZE1\|POLG_ZIKV Genome polyprotein

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