Structure of PDB 5ywv Chain B Binding Site BS02

Receptor Information
>5ywv Chain B (length=224) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LPHGHMQTLIFLDLEATGLPSSRPEVTELCLLAVHRRALENTSISQGHPP
PVPRPPRVVDKLSLCIAPGKACSPGASEITGLSKAELEVQGRQRFDDNLA
ILLRAFLQRQPQPCCLVAHNGDRYDFPLLQTELARLSTPSPLDGTFCVDS
IAALKALEQASSSRKSYSLGSIYTRLYWQAPTDSHTAEGDVLTLLSICQW
KPQALLQWVDEHARPFSTVKPMYG
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5ywv Chain B Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5ywv Structural basis for overhang excision and terminal unwinding of DNA duplexes by TREX1
Resolution2.3 Å
Binding residue
(original residue number in PDB)		D18 E20 D200
Binding residue
(residue number reindexed from 1)		D13 E15 D190
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:5ywv, PDBe:5ywv, PDBj:5ywv
PDBsum5ywv
PubMed29734329
UniProtQ91XB0|TREX1_MOUSE Three-prime repair exonuclease 1 (Gene Name=Trex1)

[Back to BioLiP]