Structure of PDB 5y3k Chain B Binding Site BS02

Receptor Information
>5y3k Chain B (length=750) Species: 9796 (Equus caballus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLPPFLPCELQPHGLVNCNWLFLKSVPHFSAAAPRDNVTSLSLLSNRIHH
LHDSDFAQLSNLQKLNLKWNCPPAGLSPMHFPCHMTIEPNTFLAVPTLEE
LNLSYNGITTVPALPSSLVSLILSRTNILQLDPTSLTGLHALRFLYMDGN
CYYKNPCGRALEVAPGALLGLGNLTHLSLKYNNLTTVPRSLPPSLEYLLL
SYNHIVTLAPEDLANLTALRVLDVGGNCRRCDHARNPCVECPHKFPQLHS
DTFSHLSRLEGLVLKDSSLYQLNPRWFRGLGNLTVLDLSENFLYDCITKT
KAFQGLAQLRRLNLSFNYHKKVSFAHLTLAPSFGSLLSLQELDMHGIFFR
SLSQKTLQPLARLPMLQRLYLQMNFINQAQLGIFKDFPGLRYIDLSDNRI
SGAVESEDFMPSCKNLSFTLDLSRNNLVTVQPEMFAQLSRLQCLRLSHNS
ISQAVNGSQFVPLTSLQVLDLSHNKLDLYHGRSFTELPRLEALDLSYNSQ
PFSMRGVGHNLSFVAQLPTLRYLSLAHNGIHSRVSQQLCSTSLWALDFSG
NSLSQMWAEGDLYLRFFQGLRSLIRLDLSQNRLHTLLPCTLGNLPKSLQL
LRLRNNYLAFFNWSSLTLLPNLETLDLAGNQLKALSNGSLPSGTQLQRLD
VSRNSIIFVVPGFFALATRLRELNLSANALRTVEPSWFGFLAGSLEVLDV
SANPLHCACGAAFVDFLLQVQAAVPGLPSRVKCGSPGQLQGRSIFAQDLR
Ligand information
Receptor-Ligand Complex Structure
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PDB5y3k Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation
Resolution2.7 Å
Binding residue
(original residue number in PDB)		D259 Y345 H346 K348 V349 S350 F351 A352 F375 R377 F402
Binding residue
(residue number reindexed from 1)		D232 Y318 H319 K321 V322 S323 F324 A325 F348 R350 F375
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5y3k, PDBe:5y3k, PDBj:5y3k
PDBsum5y3k
PubMed29625894
UniProtQ2EEY0|TLR9_HORSE Toll-like receptor 9 (Gene Name=TLR9)

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