Structure of PDB 5xja Chain B Binding Site BS02

Receptor Information
>5xja Chain B (length=332) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PNWEFARMIKEFRVTMECSPLTVTDPIEEHRICVCVRKRPLNKQELAKKE
IDVISVPSKCLLLVHEPKLKVDLTKYLENQAFCFDFAFDETASNEVVYRF
TARPLVQTIFEGGKATCFAYGQTGSGKTHTMGGDLQNASKGIYAMASRDV
FLLKNQPRYRNLNLEVYVTFFEIYNGKVFDLLNKKAKLRVLEDSRQQVQV
VGLQEYLVTCADDVIKMINMGSACRTSSRSHACFQILLRTKGRLHGKFSL
VDLAGNERRMEGAEINKSLLALKECIRALGQFRESKLTQVLRDSFIGENS
RTCMIAMISPGISSCEYTLNTLRYADRVKELS
Ligand information
Ligand IDAF3
InChIInChI=1S/Al.3FH/h;3*1H/q+3;;;/p-3
InChIKeyKLZUFWVZNOTSEM-UHFFFAOYSA-K
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		F[Al](F)F
FormulaAl F3
NameALUMINUM FLUORIDE
ChEMBL
DrugBank
ZINC
PDB chain5xja Chain B Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5xja Mechanism of Catalytic Microtubule Depolymerization via KIF2-Tubulin Transitional Conformation
Resolution3.43 Å
Binding residue
(original residue number in PDB)		T351 S463 D488
Binding residue
(residue number reindexed from 1)		T128 S227 D252
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement

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Molecular Function
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Biological Process
External links
PDB RCSB:5xja, PDBe:5xja, PDBj:5xja
PDBsum5xja
PubMed28903043
UniProtQ922S8|KIF2C_MOUSE Kinesin-like protein KIF2C (Gene Name=Kif2c)

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