Structure of PDB 5x94 Chain B Binding Site BS02
Receptor Information
>5x94 Chain B (length=207) Species:
9606
(Homo sapiens) [
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SRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVT
HIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPL
NCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVR
TSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLK
QPLNTTR
Ligand information
>5x94 Chain O (length=7) Species:
102608
(Helicobacter pylori F32) [
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YATIDFD
Receptor-Ligand Complex Structure
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PDB
5x94
Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins.
Resolution
2.6 Å
Binding residue
(original residue number in PDB)
R138 S140 Q141 S142 V148 H169 V181 G183 G184 M202 V203 E204 T205
Binding residue
(residue number reindexed from 1)
R136 S138 Q139 S140 V146 H156 V168 G170 G171 M189 V190 E191 T192
Enzymatic activity
Enzyme Commision number
3.1.3.48
: protein-tyrosine-phosphatase.
External links
PDB
RCSB:5x94
,
PDBe:5x94
,
PDBj:5x94
PDBsum
5x94
PubMed
28930683
UniProt
Q06124
|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)
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