Structure of PDB 5x6h Chain B Binding Site BS02

Receptor Information
>5x6h Chain B (length=115) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPAVKRLLEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPGQPSKCVTI
PRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQ
KEVCINPYHYKRVES
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5x6h Chain B Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5x6h Structural basis for the Smad5 MH1 domain to recognize different DNA sequences.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		C110 C122 H127
Binding residue
(residue number reindexed from 1)		C92 C104 H109
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005667 transcription regulator complex

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Biological Process
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Cellular Component
External links
PDB RCSB:5x6h, PDBe:5x6h, PDBj:5x6h
PDBsum5x6h
PubMed26304548
UniProtP97454|SMAD5_MOUSE Mothers against decapentaplegic homolog 5 (Gene Name=Smad5)

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