Structure of PDB 5x3s Chain B Binding Site BS02
Receptor Information
>5x3s Chain B (length=223) Species:
10090
(Mus musculus) [
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
ECHLSDLLQQLTSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPN
SLMKKITLLNYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSA
IILHLSNGTVQINFFQDHTKLILCPLMAAVTYINEKRDFQTYRLSLLEEY
GCCKELASRLRYARTMVDKLLSS
Ligand information
>5x3s Chain D (length=8) Species:
9606
(Homo sapiens) [
Search peptide sequence
] [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
HYPSTTAL
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
5x3s
Phosphorylation of human enhancer filamentation 1 (HEF1) stimulates interaction with Polo-like kinase 1 leading to HEF1 localization to focal adhesions.
Resolution
2.899 Å
Binding residue
(original residue number in PDB)
W414 D416 Y485 H489 L490 L491 R516 H538 K540
Binding residue
(residue number reindexed from 1)
W44 D46 Y115 H119 L120 L121 R146 H168 K170
Enzymatic activity
Enzyme Commision number
2.7.11.21
: polo kinase.
External links
PDB
RCSB:5x3s
,
PDBe:5x3s
,
PDBj:5x3s
PDBsum
5x3s
PubMed
29191835
UniProt
Q07832
|PLK1_MOUSE Serine/threonine-protein kinase PLK1 (Gene Name=Plk1)
[
Back to BioLiP
]
