Structure of PDB 5w0n Chain B Binding Site BS02
Receptor Information
>5w0n Chain B (length=372) Species:
9606
(Homo sapiens) [
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LEPLPPLTPKFLNILDQVCIQCYKDFSPTIIEDQAREHIRQNLESFIRQD
FPGTKLSLFGSSKNGFGFKQSDLDVCMTINGLETAEGLDCVRTIEELARV
LRKHSGLRNILPITTAKVPIVKFFHLRSGLEVDISLYNTLALHNTRLLSA
YSAIDPRVKYLCYTMKVFTKMCDIGDASRGSLSSYAYTLMVLYFLQQRNP
PVIPVLQEIYKGEKKPEIFVDGWNIYFFDQIDELPTYWSECGKNTESVGQ
LWLGLLRFYTEEFDFKEHVISIRRKSLLTTFKKQWTSKYIVIEDPFDLNH
NLGAGLSRKMTNFIMKAFINGRRVFGIPVKGYPSKMEYFFDPDVLTEGEL
APNDRCCRICGKIGHFMKDCPM
Ligand information
Ligand ID
2KH
InChI
InChI=1S/C9H16N3O14P3/c13-5-1-2-12(9(16)10-5)8-7(15)6(14)4(25-8)3-24-27(17,18)11-28(19,20)26-29(21,22)23/h1-2,4,6-8,14-15H,3H2,(H,10,13,16)(H2,21,22,23)(H3,11,17,18,19,20)/t4-,6-,7-,8-/m1/s1
InChIKey
OZIBFYOFLVBDIY-XVFCMESISA-N
SMILES
Software
SMILES
OpenEye OEToolkits 1.7.6
C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(NP(=O)(O)OP(=O)(O)O)O)O)O
ACDLabs 12.01
O=P(O)(O)OP(=O)(O)NP(=O)(O)OCC2OC(N1C(=O)NC(=O)C=C1)C(O)C2O
CACTVS 3.385
O[CH]1[CH](O)[CH](O[CH]1CO[P](O)(=O)N[P](O)(=O)O[P](O)(O)=O)N2C=CC(=O)NC2=O
CACTVS 3.385
O[C@H]1[C@@H](O)[C@@H](O[C@@H]1CO[P](O)(=O)N[P](O)(=O)O[P](O)(O)=O)N2C=CC(=O)NC2=O
OpenEye OEToolkits 1.7.6
C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(NP(=O)(O)OP(=O)(O)O)O)O)O
Formula
C9 H16 N3 O14 P3
Name
5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine
ChEMBL
DrugBank
ZINC
ZINC000098208190
PDB chain
5w0n Chain B Residue 1402 [
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Receptor-Ligand Complex Structure
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PDB
5w0n
Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis.
Resolution
2.497 Å
Binding residue
(original residue number in PDB)
F1045 G1046 S1047 S1057 D1058 D1060 N1130 K1152 S1170 Y1171 L1288
Binding residue
(residue number reindexed from 1)
F59 G60 S61 S71 D72 D74 N144 K166 S184 Y185 L302
Annotation score
2
Enzymatic activity
Enzyme Commision number
2.7.7.52
: RNA uridylyltransferase.
Gene Ontology
Molecular Function
GO:0003676
nucleic acid binding
GO:0008270
zinc ion binding
View graph for
Molecular Function
External links
PDB
RCSB:5w0n
,
PDBe:5w0n
,
PDBj:5w0n
PDBsum
5w0n
PubMed
28671666
UniProt
Q5VYS8
|TUT7_HUMAN Terminal uridylyltransferase 7 (Gene Name=TUT7)
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