Structure of PDB 5vqi Chain B Binding Site BS02

Receptor Information

>5vqi Chain B (length=421) Species: 5141 (Neurospora crassa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DLPKMVEGVFSSEIDKQIQATTKFRKLLSKERNPPIEEVIKTGVVGRFVE
FLRSPHTLVQFEAAWALTNIASGSATQTQVVIEAGAVPIFVELLGSPEPD
VREQAVWALGNIAGDSPQCRDYVLSCGALRPLLTLLGDSRKLSMLRNATW
TLSNFCRGKTPQPDWNTIAPALPVLAKLVYSLDDEVLIDACWAISYLSDG
SNDKIQAVIEAGIPRRLVELLMHASTSVQTPALRSVGNIVTGDDVQTQVI
INCGALPCLLSLLSSNKDGIRKEACWTISNITAGNSAQIQSVIDANIIPP
LIHLLSHADLKTRKEACWAISNATSGGLQKPDQIRYLVAQGCIKPLCDLL
ACPDNKIIQVALDGLENILKVGELDKNAASINRYALFIEECGGMEKIHDC
QTNANEEIYMKAYNIIEKYFS

Ligand information

>5vqi Chain C (length=6) Species: 5141 (Neurospora crassa) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

SKRQRR

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5vqi Nuclear transport of the Neurospora crassa NIT-2 transcription factor is mediated by importin-alpha.
Resolution	2.501 Å
Binding residue (original residue number in PDB)	R315 N319 T328 E354 W357 N361 A364 E396 W399
Binding residue (residue number reindexed from 1)	R234 N238 T247 E273 W276 N280 A283 E315 W318

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0061608	nuclear import signal receptor activity

	Biological Process
GO:0006606	protein import into nucleus

	Cellular Component
GO:0005737	cytoplasm

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Cellular Component

External links

PDB	RCSB:5vqi, PDBe:5vqi, PDBj:5vqi
PDBsum	5vqi
PubMed	29054975
UniProt	Q9C2K9

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