Structure of PDB 5vbn Chain B Binding Site BS02

Receptor Information
>5vbn Chain B (length=125) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SYVLPEVICRSCNFCRDLDLCKDSSPQWLCSNCQAPYDSSAIEMTLVEVL
QKKLMAFTLQDLVCLKCRGVKETSMPVYCSCAGDFALTIHTQVFMEQIGI
FRNIAQHYGMSYLLETLEWLLQKNP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5vbn Chain B Residue 2302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5vbn Crystal structure of the human Pol B-subunit in complex with the C-terminal domain of the catalytic subunit.
Resolution2.35 Å
Binding residue
(original residue number in PDB)		C2221 C2224 C2236
Binding residue
(residue number reindexed from 1)		C64 C67 C79
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
Cellular Component
GO:0008622 epsilon DNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5vbn, PDBe:5vbn, PDBj:5vbn
PDBsum5vbn
PubMed28747437
UniProtQ07864|DPOE1_HUMAN DNA polymerase epsilon catalytic subunit A (Gene Name=POLE)

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