Structure of PDB 5udh Chain B Binding Site BS02

Receptor Information

>5udh Chain B (length=381) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DYRYEVLTAEQILQHMVECIREVNEVIQNPATITRILLSHFNWDKEKLME
RYFDGMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIMEEGMGQT
ISCPAHGCDILVDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPA
PDCHHVVKVQYPDAKPVRCKCGRQFCFNCGENWHDPVKCKWLKKWIKKCD
NTKECPKCHVTIEKDGGCNHMVCRNQNCKAEFCWVCLGPWEPHGSAWYNC
NRAALQRYLFYCNRYMNHMQSLRFEHKLYAQVKQKFLKKAVDVLCQCRAT
LMYTYVFAFYLKKNNQSIIFENNQADLENATEVLSGYLERDISQDSLQDI
KQKVQDKYRYCESRRRVLLQHVHEGYEKDLW

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

5udh Chain B Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5udh Structural Studies of HHARI/UbcH7Ub Reveal Unique E2Ub Conformational Restriction by RBR RING1.
Resolution	3.24 Å
Binding residue (original residue number in PDB)	C372 C375 H382 C389
Binding residue (residue number reindexed from 1)	C233 C236 H243 C250
Annotation score	4

Enzymatic activity

Enzyme Commision number

2.3.2.31: RBR-type E3 ubiquitin transferase.

Gene Ontology

	Molecular Function
GO:0004842	ubiquitin-protein transferase activity
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

	Biological Process
GO:0016567	protein ubiquitination

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Molecular Function

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Biological Process

External links

PDB	RCSB:5udh, PDBe:5udh, PDBj:5udh
PDBsum	5udh
PubMed	28552575
UniProt	Q9Y4X5\|ARI1_HUMAN E3 ubiquitin-protein ligase ARIH1 (Gene Name=ARIH1)

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