Structure of PDB 5tht Chain B Binding Site BS02
Receptor Information
>5tht Chain B (length=360) Species:
9606
(Homo sapiens) [
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VPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASM
EEMATFHTDAYLQHLQKVSQDHPDSIEYGLGYDCPATEGIFDYAAAIGGA
TITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRK
FERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVG
LGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADT
IAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGAGGYNLANTARCWTYL
TGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNY
IKGNLKHVVI
Ligand information
Ligand ID
ZN
InChI
InChI=1S/Zn/q+2
InChIKey
PTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.341
[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Zn+2]
Formula
Zn
Name
ZINC ION
ChEMBL
CHEMBL1236970
DrugBank
DB14532
ZINC
PDB chain
5tht Chain B Residue 402 [
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Receptor-Ligand Complex Structure
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PDB
5tht
Structural and Functional Influence of the Glycine-Rich Loop G302GGGY on the Catalytic Tyrosine of Histone Deacetylase 8.
Resolution
2.407 Å
Binding residue
(original residue number in PDB)
D178 H180 D267
Binding residue
(residue number reindexed from 1)
D160 H162 D249
Annotation score
1
Enzymatic activity
Enzyme Commision number
3.5.1.-
3.5.1.98
: histone deacetylase.
Gene Ontology
Molecular Function
GO:0004407
histone deacetylase activity
GO:0005515
protein binding
GO:0016787
hydrolase activity
GO:0030544
Hsp70 protein binding
GO:0033558
protein lysine deacetylase activity
GO:0046872
metal ion binding
GO:0051879
Hsp90 protein binding
GO:0140297
DNA-binding transcription factor binding
GO:0160008
protein decrotonylase activity
GO:0160009
histone decrotonylase activity
Biological Process
GO:0000122
negative regulation of transcription by RNA polymerase II
GO:0006325
chromatin organization
GO:0007064
mitotic sister chromatid cohesion
GO:0031397
negative regulation of protein ubiquitination
GO:0031647
regulation of protein stability
GO:0032204
regulation of telomere maintenance
GO:0040029
epigenetic regulation of gene expression
Cellular Component
GO:0000118
histone deacetylase complex
GO:0000228
nuclear chromosome
GO:0005634
nucleus
GO:0005654
nucleoplasm
GO:0005694
chromosome
GO:0005737
cytoplasm
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:5tht
,
PDBe:5tht
,
PDBj:5tht
PDBsum
5tht
PubMed
27933794
UniProt
Q9BY41
|HDAC8_HUMAN Histone deacetylase 8 (Gene Name=HDAC8)
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