Structure of PDB 5t9j Chain B Binding Site BS02

Receptor Information
>5t9j Chain B (length=391) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GVNDLWQILEPVKQHIPLRNLGGKTIAVNLSLWVCEAQTVKKMMGSVMKP
HLRNLFFRISYLTQMDVKLVFVMEGEPPKLRYGSSGKSWSQKTGRSHFKS
VLRECLHMLECLGIPWVQAAGEAEAMCAYLNAGGHVDGCLTNDGDTFLYG
AQTVYRNFTMNTKDPHVDCYTMSSIKSKLGLDRDALVGLAILLGCDYLPK
GVPGVGKEQALKLIQILKGQSLLQRFNRWNQLNEVENNIKKKACCCEGFP
FHEVIQEFLLNKDKLVKVIRYQRPDLLLFQRFTLEKMEWPNHYACEKLLV
LLTHYDMIERKLGSRNSNQLQPIRIVKTRIRNGVHCFEIEWEKPEHYAME
DKQHGEFALLTIEEESLFEAAYPEIVAVYQKQKLEIKGKKQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5t9j Human Holliday junction resolvase GEN1 uses a chromodomain for efficient DNA recognition and cleavage.
Resolution3.00013 Å
Binding residue
(original residue number in PDB)		M44 R54 R406 I407 N409
Binding residue
(residue number reindexed from 1)		M43 R53 R329 I330 N332
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity

View graph for
Molecular Function
External links
PDB RCSB:5t9j, PDBe:5t9j, PDBj:5t9j
PDBsum5t9j
PubMed26682650
UniProtQ17RS7|GEN_HUMAN Flap endonuclease GEN homolog 1 (Gene Name=GEN1)

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