Structure of PDB 5t5c Chain B Binding Site BS02

Receptor Information
>5t5c Chain B (length=296) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VLEQFGFPLTGTEARCYTNHALSYDQAKRVPRWVLEHISKSKIMGDADRK
HCKFKPDPNIPPTFSAFNEDYVGSGWSRGAMAPAGNNKFSSKAMAETFYL
SNIVPQDFDNNSGYWNRIEMYCRELTERFEDVWVVSGPLTLPQTRGDGKK
IVSYQVIGEDNVAVPSHLYKVILARRSSVSTEPLALGAFVVPNEAIGFQP
QLTEFQVSLQDLEKLSGLVFFPHLDRTSDIRNICSVDTCKLLDFQEFTLY
LSTRKIEGARSVLRLEKIMENLKNAEIEPDDYFMSRYEKKLEELKA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5t5c A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease.
Resolution1.851 Å
Binding residue
(original residue number in PDB)		K113 S172 K315 R320 R324
Binding residue
(residue number reindexed from 1)		K53 S112 K255 R260 R264
Binding affinityPDBbind-CN: Kd=4.13uM
Enzymatic activity
Catalytic site (original residue number in PDB) C112 A140 N162 N171 E179
Catalytic site (residue number reindexed from 1) C52 A80 N102 N111 E119
Enzyme Commision number 3.1.30.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5t5c, PDBe:5t5c, PDBj:5t5c
PDBsum5t5c
PubMed28466855
UniProtQ9Y2C4|EXOG_HUMAN Nuclease EXOG, mitochondrial (Gene Name=EXOG)

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