Structure of PDB 5sth Chain B Binding Site BS02

Receptor Information
>5sth Chain B (length=300) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNTVPFTSAPIEVTIGIDQYSFNVKENQPFHGIKDIPIGHVHVIHFQHAD
NSSMRYGYWFDCRMGNFYIQYDPKDGLYKMMEERDGAKFENIVHNFKERQ
MMVSYPKIDEDDTWYNLTEFVQMDKIRKIVRKDENQFSYVDSSMTTVQEN
ELSDPAHSLNYTVINFKSREAIRPGHEMEDFLDKSYYLNTVMLQGIFKNS
SNYFGELQFAFLNAMFFGNYGSSLQWHAMIELICSSATVPKHMLDKLDEI
LYYQIKTLPEQYSDILLNERVWNICLYSSFQKNSLHNTEKIMENKYPELL
Ligand information
Ligand ID8K2
InChIInChI=1S/C4H4ClNO2S2/c5-3-1-2-4(9-3)10(6,7)8/h1-2H,(H2,6,7,8)
InChIKeyRKLQLYBJAZBSEU-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.6c1cc(sc1S(=O)(=O)N)Cl
CACTVS 3.385N[S](=O)(=O)c1sc(Cl)cc1
FormulaC4 H4 Cl N O2 S2
Name5-chloranylthiophene-2-sulfonamide
ChEMBLCHEMBL447118
DrugBank
ZINCZINC000001037567
PDB chain5sth Chain B Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5sth Large-Scale Crystallographic Fragment Screening Expedites Compound Optimization and Identifies Putative Protein-Protein Interaction Sites.
Resolution1.67 Å
Binding residue
(original residue number in PDB)		G235 N236 Y237 S240 I282
Binding residue
(residue number reindexed from 1)		G218 N219 Y220 S223 I265
Annotation score1
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:5sth, PDBe:5sth, PDBj:5sth
PDBsum5sth
PubMed36260741
UniProtP32357|AAR2_YEAST A1 cistron-splicing factor AAR2 (Gene Name=AAR2)

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