Structure of PDB 5oyb Chain B Binding Site BS02

Receptor Information
>5oyb Chain B (length=718) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDYHEDDKRFRREELCREAEFLKLKMPTKKVYHISETRGLLKTINSVLQK
ITDPIQPKVAEHRPQTTKRLSYPFSREKQHLFDLTDRDSFFDSKTRSTIV
YEILKRTTCGITSLLANGVYSAAYPLHDGDYEGDNVEFNDRKLLYEEWAS
YGVFYKYQPIDLVRKYFGEKVGLYFAWLGAYTQMLIPASIVGVIVFLYGC
ATVDENIPSMEMCDQRYNITMCPLCDKTCSYWKMSSACATARASHLFDNP
ATVFFSVFMALWAATFMEHWKRKQMRLNYRWDLTGFEEEEEAVKDHPRAE
YEARVLEKSPAYFTNLVSIIFMIAVTFAIVLGVIIYRISTAAALAMNSSP
SVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEKSFEE
RLTFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPG
GCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKFIRYLKRKQRYEVDFN
LEPFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKF
VTELRRPVAIRAKDIGIWYNILRGVGKLAVIINAFVISFTSDFIPRLVYL
YMYSQNGTMHGFVNHTLSSFNVSDFQNGTAPNDPLDLGYEVQICRYKDYR
EPPWSEHKYDISKDFWAVLAARLAFVIVFQNLVMFMSDFVDWVIPDIPKD
ISQQIHKEKVLMVELFMR
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5oyb Chain B Residue 1002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5oyb Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM.
Resolution3.75 Å
Binding residue
(original residue number in PDB)		N650 N651 E654 E705 E734
Binding residue
(residue number reindexed from 1)		N472 N473 E476 E513 E542
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005229 intracellularly calcium-gated chloride channel activity
GO:0005247 voltage-gated chloride channel activity
GO:0005254 chloride channel activity
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006821 chloride transport
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0034220 monoatomic ion transmembrane transport
GO:0034605 cellular response to heat
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042391 regulation of membrane potential
GO:0050965 detection of temperature stimulus involved in sensory perception of pain
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0051649 establishment of localization in cell
GO:0060438 trachea development
GO:0070254 mucus secretion
GO:0106091 glial cell projection elongation
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016324 apical plasma membrane
GO:0034707 chloride channel complex
GO:0042734 presynaptic membrane
GO:0042995 cell projection
GO:0045202 synapse
GO:0098793 presynapse
GO:0098978 glutamatergic synapse

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5oyb, PDBe:5oyb, PDBj:5oyb
PDBsum5oyb
PubMed29236691
UniProtQ8BHY3|ANO1_MOUSE Anoctamin-1 (Gene Name=Ano1)

[Back to BioLiP]