Structure of PDB 5o26 Chain B Binding Site BS02

Receptor Information
>5o26 Chain B (length=267) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDEQQRF
KEEAEMLKGLQHPNIVRFYDSWESKCIVLVTELMTSGTLKTYLKRFKVMK
PKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLG
LATLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEY
PYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSI
RDLLNHAFFAEDTGLRV
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5o26 Chain B Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5o26 Crystal structure of WNK3 kinase domain in a diphosphorylated state and in complex with AMP-PNP/Mg2+
Resolution2.379 Å
Binding residue
(original residue number in PDB)		N280 D294
Binding residue
(residue number reindexed from 1)		N134 D148
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D275 K277 D279 N280 D294 M301 P313
Catalytic site (residue number reindexed from 1) D129 K131 D133 N134 D148 M155 P167
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5o26, PDBe:5o26, PDBj:5o26
PDBsum5o26
PubMed
UniProtQ9BYP7|WNK3_HUMAN Serine/threonine-protein kinase WNK3 (Gene Name=WNK3)

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