Structure of PDB 5nhk Chain B Binding Site BS02

Receptor Information
>5nhk Chain B (length=132) Species: 263 (Francisella tularensis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DLKEFGFKVTQPRVEILKLFEKNKDKHLSPDDVFSKLKAQGSTTGIATVY
RVLNQFESAGIINRLKLDNEQVMYELNQGEHHDHIICVKCNMIQEFYSPG
IEALQKQIVESFGAEMIDYSLNIYVKCKSCRE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5nhk Chain B Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5nhk Structural and functional studies of the metalloregulator Fur identify a promoter-binding mechanism and its role inFrancisella tularensisvirulence.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		C93 C96 C133 C136
Binding residue
(residue number reindexed from 1)		C87 C90 C127 C130
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045892 negative regulation of DNA-templated transcription
GO:1900705 negative regulation of siderophore biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:5nhk, PDBe:5nhk, PDBj:5nhk
PDBsum5nhk
PubMed30271974
UniProtQ5NIN6

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