Structure of PDB 5mpf Chain B Binding Site BS02

Receptor Information

>5mpf Chain B (length=202) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

NNFEYTLEASKSLRQKSTMTYLNKGQFYPITLKEVSSKVRSVIMVVFAED
KSREDQLRHWKYWHSRQHTAKQRCIDIADYKESFNTISNVEEIAYNAISF
TWDINDEAKVFISVNCLSTDFSSQKGVKGLPLNIQIDTYSYNNRSNKPVH
RAYCQIKVFCDKGAERKIRDEERKQSKRKMDITVFKPFIDLDTQPVLFIP
DV

Ligand information

>5mpf Chain F (length=12) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

aaaaccggtttt

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5mpf Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family.
Resolution	2.918 Å
Binding residue (original residue number in PDB)	T380 C421 R427 K428
Binding residue (residue number reindexed from 1)	T119 C160 R166 K167
Binding affinity	PDBbind-CN: Kd=90nM

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003700	DNA-binding transcription factor activity

	Biological Process
GO:0006357	regulation of transcription by RNA polymerase II

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Molecular Function

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Biological Process

External links

PDB	RCSB:5mpf, PDBe:5mpf, PDBj:5mpf
PDBsum	5mpf
PubMed	29309642
UniProt	Q9NZI5\|GRHL1_HUMAN Grainyhead-like protein 1 homolog (Gene Name=GRHL1)

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