Structure of PDB 5mhk Chain B Binding Site BS02

Receptor Information
>5mhk Chain B (length=197) Species: 10298 (Human alphaherpesvirus 1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QPRRVELDADATSGAFYARYRDGYVSGEPWPGAGPPPPGRVLYGGLGDSR
PGLWGAPEAEEARRRFEASGAPAAVWAPELGDAAQQYALITRLLYTPDAE
AMGWLQNPRVVPGDVALDQACFRISGAARNSFITGSVARAVPHLGYAMAA
GRFGWGLAHAAAAVAMSRRYDRAQKGFLLTSLRRAYAPLLARENAAL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5mhk The herpes viral transcription factor ICP4 forms a novel DNA recognition complex.
Resolution2.28 Å
Binding residue
(original residue number in PDB)		N393 N416 I421 R456
Binding residue
(residue number reindexed from 1)		N107 N130 I133 R168
Binding affinityPDBbind-CN: Kd=1.6nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0045893 positive regulation of DNA-templated transcription

View graph for
Biological Process
External links
PDB RCSB:5mhk, PDBe:5mhk, PDBj:5mhk
PDBsum5mhk
PubMed28505309
UniProtP08392|ICP4_HHV11 Major viral transcription factor ICP4 (Gene Name=ICP4)

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