Structure of PDB 5mfv Chain B Binding Site BS02

Receptor Information
>5mfv Chain B (length=251) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVK
LVPDGKYGAQNGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFM
TLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEK
MWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQ
IGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGC
P
Ligand information
Ligand ID5PX
InChIInChI=1S/C10H12N2O3S/c13-8-3-4-9-10(5-8)16(14,15)11-6-12(9)7-1-2-7/h3-5,7,11,13H,1-2,6H2
InChIKeyOMEAYSCNDLQLNC-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385Oc1ccc2N(CN[S](=O)(=O)c2c1)C3CC3
OpenEye OEToolkits 1.7.6c1cc2c(cc1O)S(=O)(=O)NCN2C3CC3
FormulaC10 H12 N2 O3 S
Name4-Cyclopropyl-3,4-dihydro-7-hydroxy-2H-1,2,4-benzothiadiazine 1,1-dioxide;
BPAM-521
ChEMBL
DrugBank
ZINCZINC000118234308
PDB chain5mfv Chain A Residue 902 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5mfv Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors.
Resolution2.181 Å
Binding residue
(original residue number in PDB)		K531 P532 F533 M534 Q786
Binding residue
(residue number reindexed from 1)		K97 P98 F99 M100 Q232
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:5mfv, PDBe:5mfv, PDBj:5mfv
PDBsum5mfv
PubMed28360094
UniProtP22756|GRIK1_RAT Glutamate receptor ionotropic, kainate 1 (Gene Name=Grik1)

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