Structure of PDB 5luz Chain B Binding Site BS02

Receptor Information

>5luz Chain B (length=665) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GSSSYTVAGRNVLRWDLSPEQIKTRTEELIVQTKQVYDAVGMLGIEEVTY
ENCLQALADVEVKYIVERTMLDFPQHVSSDKEVRAASTEADKRLSRFDIE
MSMRGDIFERIVHLQETCDLGKIKPEARRYLEKSIKMGKRNGLHLPEQVQ
NEIKSMKKRMSELCIDFNKNLNEDDTFLVFSKAELGALPDDFIDSLEKTD
DDKYKITLKYPHYFPVMKKCCIPETRRRMEMAFNTRCKEENTIILQQLLP
LRTKVAKLLGYSTHADFVLEMNTAKSTSRVTAFLDDLSQKLKPLGEAERE
FILNLKKKECKDRGFEYDGKINAWDLYYYMTQTEELKYSIDQEFLKEYFP
IEVVTEGLLNTYQELLGLSFEQMTDAHVWNKSVTLYTVKDKATGEVLGQF
YLDLYPREGKYNHAACFGLQPGCLLPDGSRMMAVAALVVNFSQGRPSLLR
HDEVRTYFHQFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWD
VDSLRRLSKHYKDGSPIADDLLEKLVASRLVNTGLLTLRQIVLSKVDQSL
HTNTSLDAASEYAKYCSEILGVAATPGTNMPATFGHLAGGYDGQYYGYLW
SEVFSMDMFYSCFKKEGIMNPEVGMKYRNLILKPGGSLDGMDMLHNFLKR
EPNQKAFLMSRGLHA

Ligand information

>5luz Chain Q (length=3) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

YIL

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5luz Mechanism of Peptide Binding and Cleavage by the Human Mitochondrial Peptidase Neurolysin.
Resolution	2.7 Å
Binding residue (original residue number in PDB)	Y222 Y339 R554 Y610 Y613
Binding residue (residue number reindexed from 1)	Y210 Y327 R539 Y595 Y598

Enzymatic activity

Enzyme Commision number

3.4.24.16: neurolysin.

Gene Ontology

	Molecular Function
GO:0004222	metalloendopeptidase activity
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0042277	peptide binding
GO:0046872	metal ion binding

	Biological Process
GO:0006111	regulation of gluconeogenesis
GO:0006508	proteolysis
GO:0006518	peptide metabolic process
GO:0007186	G protein-coupled receptor signaling pathway
GO:1902809	regulation of skeletal muscle fiber differentiation

	Cellular Component
GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005758	mitochondrial intermembrane space
GO:0005829	cytosol
GO:0005886	plasma membrane

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:5luz, PDBe:5luz, PDBj:5luz
PDBsum	5luz
PubMed	29183787
UniProt	Q9BYT8\|NEUL_HUMAN Neurolysin, mitochondrial (Gene Name=NLN)

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