Structure of PDB 5kyn Chain B Binding Site BS02

Receptor Information
>5kyn Chain B (length=719) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTTYLEFIQQNEERDGVRFSWNVWPSSRLEATRMVVPVAALFTPLKERPD
LPPIQYEPVLCSRTTCRAVLNPLCQVDYRAKLWACNFCYQRNQFPPSYAG
ISELNQPAELLPQFSSIEYVVLRGPQMPLIFLYVVDTCMEDEDLQALKES
MQMSLSLLPPTALVGLITFGRMVQVHELGCEGISKSYVFRGTKDLSAKQL
QEMLGLSKVPSNRFLQPVQKIDMNLTDLLGELQRDPWPVPQGKRPLRSSG
VALSIAVGLLECTFPNTGARIMMFIGGPATQGPGMVVGDELKTPIRSWHD
IDKDNAKYVKKGTKHFEALANRAATTGHVIDIYACALDQTGLLEMKCCPN
LTGGYMVMGDSFNTSLFKQTFQRVFTKDMHGQFKMGFGGTLEIKTSREIK
ISGAIGPCVSLNSKGPCVSENEIGTGGTCQWKICGLSPTTTLAIYFEVVA
GRGAIQFVTQYQHSSGQRRIRVTTIARNWADAQTQIQNIAASFDQEAAAI
LMARLAIYRAETEEGPDVLRWLDRQLIRLCQKFGEYHKDDPSSFRFSETF
SLYPQFMFHLRRSSFLQVFNNSPDESSYYRHHFMRQDLTQSLIMIQPILY
AYSFSGPPEPVLLDSSSILADRILLMDTFFQILIYHGETIAQWRKSGYQD
MPEYENFRHLLQAPVDDAQEILHSRFPMPRYIDTEHGGSQARFLLSKVNL
TDDVSLQVFMDHLKKLAVS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5kyn Chain B Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5kyn TANGO1/cTAGE5 receptor as a polyvalent template for assembly of large COPII coats.
Resolution2.552 Å
Binding residue
(original residue number in PDB)		C61 C66 C85
Binding residue
(residue number reindexed from 1)		C61 C66 C85
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0072659 protein localization to plasma membrane
GO:0090110 COPII-coated vesicle cargo loading
GO:0090114 COPII-coated vesicle budding
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016020 membrane
GO:0030127 COPII vesicle coat
GO:0030134 COPII-coated ER to Golgi transport vesicle
GO:0031410 cytoplasmic vesicle
GO:0048471 perinuclear region of cytoplasm
GO:0070971 endoplasmic reticulum exit site

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5kyn, PDBe:5kyn, PDBj:5kyn
PDBsum5kyn
PubMed27551091
UniProtQ15436|SC23A_HUMAN Protein transport protein Sec23A (Gene Name=SEC23A)

[Back to BioLiP]