Structure of PDB 5kiw Chain B Binding Site BS02

Receptor Information
>5kiw Chain B (length=447) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKK
RREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKR
IHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEF
KVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESWNEVGYDDIGGCRKQL
AQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETG
AFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKR
EKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRF
DREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAA
LCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSN
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5kiw Chain B Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5kiw Structural basis for nucleotide-modulated p97 association with the ER membrane.
Resolution3.41 Å
Binding residue
(original residue number in PDB)		T252 D304
Binding residue
(residue number reindexed from 1)		T239 D291
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.6: vesicle-fusing ATPase.
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:5kiw, PDBe:5kiw, PDBj:5kiw
PDBsum5kiw
PubMed29238611
UniProtP55072|TERA_HUMAN Transitional endoplasmic reticulum ATPase (Gene Name=VCP)

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