Structure of PDB 5jmv Chain B Binding Site BS02

Receptor Information

>5jmv Chain B (length=321) Species: 243232 (Methanocaldococcus jannaschii DSM 2661)

MDPMICLGLEGTAEKTGVGIVTSDGEVLFNKTIMINPREAADHHAETFPK
LIKEAFEVVDKNEIDLIAFSQGPGLGPSLRVTATVARTLSLTLKKPIIGV
NHCIAHIEIGKLTTEAEDPLTLYVSGGNTQVIAYVSKKYRVFGETLDIAV
GNCLDQFARYVNLPHPGGPYIEELARKGKKLVDLPYTVKGMDIAFSGLLT
AAMRAYDAGERLEDICYSLQEYAFSMLTEITERALAHTNKGEVMLVGGVA
ANNRLREMLKAMCEGQNVDFYVPPKEFCGDNGAMIAWLGLLMHKNGRWMS
LDETKIIPNYRTDMVEVNWIK

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 5jmv Chain B Residue 402

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5jmv Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis.
• Resolution: 3.38647 Å
• Binding residue (original residue number in PDB): H106 H110 Y127 S129 D284
• Binding residue (residue number reindexed from 1): H102 H106 Y123 S125 D280
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.3.1.234: N(6)-L-threonylcarbamoyladenine synthase.
  2.7.11.1: non-specific serine/threonine protein kinase.

Gene Ontology

Biological Process

• GO:0002949 tRNA threonylcarbamoyladenosine modification

Cellular Component

• GO:0000408 EKC/KEOPS complex

External links

• PDB: RCSB:5jmv, PDBe:5jmv, PDBj:5jmv
• PDBsum: 5jmv
• PubMed: 27302132
• UniProt: Q58530|KAE1B_METJA Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein (Gene Name=MJ1130)